CDKI-73

Product Specifications

CAS Number

1421693-22-2

Target

Apoptosis|||CDK

Related Pathways

Cell Cycle/Checkpoint|||Apoptosis

Purity

0.9811

Bioactivity

CDKI-73 is a potent CDK9 inhibitor (Ki: 4 nM) . It shows selective toxicity to CLL cells (LD50=80 nM) versus normal B cell and normal CD34+ cell (LD50>20 uM) .The inhibition of CDK9 induces apoptosis and potentiates the effect of cisplatin.

Smiles

CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(N)(=O)=O)ncc1F

Molecular Formula

C15H15FN6O2S2

Molecular Weight

394.45

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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