CBR-5884
Product Specifications
CAS Number
681159-27-3
Target
Dehydrogenase
Related Pathways
Metabolism
Purity
>99.99%
Bioactivity
CBR-5884 is an selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis. Biochemical characterization of the inhibitor revealed that it was a noncompetitive inhibitor that showed a time-dependent onset of inhibition and disrupted the oligomerization state of PHGDH
Smiles
CCOC(=O)c1sc(NC(=O)c2ccco2)c(SC#N)c1C
Molecular Formula
C14H12N2O4S2
Molecular Weight
336.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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