Calyculin A

Product Specifications

CAS Number

101932-71-2

Target

Phosphatase

Related Pathways

Metabolism

Purity

0.98

Bioactivity

Calyculin A ((-) -Calyculin A), a toxicant in the Japanese marine sponge CDiscodermia calyxC, is a selective and potent inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A), inducing hyperactivation of cryopreserved bovine spermatozoa and inhibiting radiation-induced gammaH2AX DNA repair disease in human lymphocytes. gammaH2AX DNA repair foci in human lymphocytes.

Smiles

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