BRD6989
Product Specifications
CAS Number
642008-81-9
Target
Interleukin, IL Receptor, CDK
Related Pathways
Cell Cycle/Checkpoint, Immunology/Inflammation
Purity
0.9943
Bioactivity
BRD6989 is an analog of the natural product cortistatin A (dCA) . Which inhibits CDK8 and upregulates IL-10. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes. BRD6989 selectively binds a complex of CDK8 with an IC50 of ~200 nM.
Smiles
CC1CCc2nc(N)c(C#N)c(-c3cccnc3)c2C1
Molecular Formula
C16H16N4
Molecular Weight
264.33
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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