Bragsin2
Product Specifications
CAS Number
342795-08-8
Target
MDM-2/p53, Ras, Others
Related Pathways
Apoptosis, MAPK, Others
Purity
0.9987
Bioactivity
Bragsin2 (6-methoxy-5-nitro-2- (trifluoromethyl) chromen-4-one) is a hydration-resistant cell penetrant, selective and non-competitive inhibitor of Afr guanine nucleotide exchange factor BRAG2 that inhibits Arf GTPase activation, with an IC50 of 3 μM. Bragsin2 binds at the interface between the pleckstrin homology domain of BRAG2 and the lipid bilayer, leading BRAG2 unable to activate lipidated Arf GTPase.
Smiles
COc1ccc2oc(cc(=O)c2c1[N+]([O-])=O)C(F)(F)F
Molecular Formula
C11H6F3NO5
Molecular Weight
289.16
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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