Exatecan Intermediate 4 (dihydrochloride)
Exatecan Intermediate 4 dihydrochloride (Compound 14f) is an intermediate of Exatecan (DX-8951, HY-13631) . Exatecan is an anticancer agent belonging to the class of camptothecin analogs. Exatecan interferes with the proliferation and division of tumor cells by interacting with DNA, thereby inhibiting tumor growth. Exatecan is primarily used for research of a variety of cancers including ovarian, lung and breast cancers[1].
Product Specifications
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
ADC Payload; Drug Intermediate
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/exatecan-intermediate-4-dihydrochloride.html
Purity
99.92
Solubility
DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
[H]Cl.[H]Cl.CC1=C2CCC(C(C2=C(C=C1F)N)=O)N
Molecular Formula
C11H15Cl2FN2O
Molecular Weight
281.15
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Ao Li, et al. Anti-tumor compound and use thereof. China, WO2024109949A1. 2024-05-30.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Camptothecins
Available Sizes
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