BMS-509744
Product Specifications
CAS Number
439575-02-7
Target
Others, IL Receptor, HIV Protease, Immunology/Inflammation related, Tyrosine Kinases
Related Pathways
Tyrosine Kinase/Adaptors, Microbiology/Virology, Proteases/Proteasome, Others, Immunology/Inflammation
Purity
0.997
Bioactivity
BMS-509744 is a selective, ATP-competitive Itk inhibitor with an IC50 of 19 nM. It inhibits IL-8 expression and HIV infection, ameliorates pulmonary inflammation in allergic asthma mouse models, and reduces Imiquimod-induced skin inflammation in mice.
Smiles
O=C(NC1=NC=C(S1)SC2=CC(=C(OC)C=C2C)C(=O)N3CCN(C(=O)C)CC3)C4=CC=C(C=C4)CNC(C)C(C)(C)C
Molecular Formula
C32H41N5O4S2
Molecular Weight
623.83
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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