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BMS-509744

Product Specifications

CAS Number

439575-02-7

Target

Others, IL Receptor, HIV Protease, Immunology/Inflammation related, Tyrosine Kinases

Related Pathways

Tyrosine Kinase/Adaptors, Microbiology/Virology, Proteases/Proteasome, Others, Immunology/Inflammation

Purity

0.997

Bioactivity

BMS-509744 is a selective, ATP-competitive Itk inhibitor with an IC50 of 19 nM. It inhibits IL-8 expression and HIV infection, ameliorates pulmonary inflammation in allergic asthma mouse models, and reduces Imiquimod-induced skin inflammation in mice.

Smiles

O=C(NC1=NC=C(S1)SC2=CC(=C(OC)C=C2C)C(=O)N3CCN(C(=O)C)CC3)C4=CC=C(C=C4)CNC(C)C(C)(C)C

Molecular Formula

C32H41N5O4S2

Molecular Weight

623.83

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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