BIIE-0246

Product Specifications

CAS Number

246146-55-4

Target

Neuropeptide Y Receptor

Related Pathways

Neuroscience|||GPCR/G Protein

Bioactivity

BIIE-0246 is a selective NPY2R antagonist with an IC50 of 15 nM at the rat [125I]PYY3-36 site. It reduces NPY-stimulated expression of p-AKT S473 and P-p44/42 MAPK.

Smiles

O=C1C=2C(C(C=3C(N1)=CC=CC3)N4CCN(C(CC5(CC(N[C@H](C(NCCN6C(=O)N(N(C6=O)C7=CC=CC=C7)C8=CC=CC=C8)=O)CCCNC(=N)N)=O)CCCC5)=O)CC4)=CC=CC2

Molecular Formula

C49H57N11O6

Molecular Weight

896.05

Shipping Conditions

Cool pack

Storage Temperature

-20°C

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