BIIE-0246
Product Specifications
CAS Number
246146-55-4
Target
Neuropeptide Y Receptor
Related Pathways
Neuroscience|||GPCR/G Protein
Bioactivity
BIIE-0246 is a selective NPY2R antagonist with an IC50 of 15 nM at the rat [125I]PYY3-36 site. It reduces NPY-stimulated expression of p-AKT S473 and P-p44/42 MAPK.
Smiles
O=C1C=2C(C(C=3C(N1)=CC=CC3)N4CCN(C(CC5(CC(N[C@H](C(NCCN6C(=O)N(N(C6=O)C7=CC=CC=C7)C8=CC=CC=C8)=O)CCCNC(=N)N)=O)CCCC5)=O)CC4)=CC=CC2
Molecular Formula
C49H57N11O6
Molecular Weight
896.05
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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