BI-671800
Product Specifications
CAS Number
1093108-50-9
Target
Prostaglandin Receptor, GPCR
Related Pathways
Immunology/Inflammation, Endocrinology/Hormones, GPCR/G Protein
Purity
0.9919
Bioactivity
BI-671800 (AP-761) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2) . With IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively. BI-671800 has the potential to treat poorly controlled asthma[2].
Smiles
CN(C)c1nc(Cc2ccc(NC(=O)c3ccc(cc3)C(F)(F)F)cc2)nc(N(C)C)c1CC(O)=O
Molecular Formula
C25H26F3N5O3
Molecular Weight
501.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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