BI-0252
Product Specifications
CAS Number
1818291-27-8
Target
E1/E2/E3 Enzyme, MDM-2/p53, Others
Related Pathways
Ubiquitination, Others, Apoptosis
Bioactivity
BI-0252 is an inhibitor of MDM2-p53 (IC50:4 nM) . BI-0252 can induce tumor regressions in all animals of a mouse SJSA-1 xenograft. And it concomitant induction of the tumor protein p53 (TP53) target genes and markers of apoptosis.
Smiles
C(N1[C@@]2([C@H]([C@]3([C@@]1(C[C@@H](N3)C4=CC=C(C(O)=O)C=C4)[H])[H])C5=C(F)C(Cl)=CC=C5)C=6C(NC2=O)=CC(Cl)=CC6)C7CC7
Molecular Formula
C30H26Cl2FN3O3
Molecular Weight
566.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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