BAY 60-6583
Product Specifications
CAS Number
910487-58-0
Target
Adenosine Receptor
Related Pathways
Neuroscience, GPCR/G Protein
Purity
0.998
Bioactivity
BAY 60-6583 is a potent, high-affinity adenosine A2B receptor agonist (EC50 = 3 nM) with affinity for A2B receptors that exceeds that for A1, A2A, and A3 receptors.BAY 60-6583 is cardioprotective in a model of myocardial ischemia.The Ki values for BAY 60-6583 binding to mouse, rabbit, and dog A2BAR were 750 nM, 340 nM, and 330 nM, respectively. The Ki values of BAY 60-6583 binding to A2BAR in mice, rabbits and dogs were 750 nM, 340 nM and 330 nM respectively.
Smiles
NC(=O)CSc1nc(N)c(C#N)c(-c2ccc(OCC3CC3)cc2)c1C#N
Molecular Formula
C19H17N5O2S
Molecular Weight
379.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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