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Barbadin

Product Specifications

CAS Number

356568-70-2

Target

Arrestin, Apoptosis

Related Pathways

GPCR/G Protein, Apoptosis

Purity

0.991

Bioactivity

Barbadin is a novel and specific inhibitor of β-arrestin/β2-adaptin interaction with an IC50 value of 19.1 μM for β-arestin1 and 15.6 μM for β-arestin2. Barbadin potentiates the long term effects of lorcaserin on POMC neurons and weight loss. Barbadin potentiates the long-term effects of lorcaserin on POMC neurons and weight loss, blocks agonist-promoted endocytosis of prototypic β2-adrenergic, V2-vasopressin, and angiotensin-II-1 receptors, and may be useful in the study of obesity.

Smiles

Nn1cnc2scc(-c3ccc(Cc4ccccc4)cc3)c2c1=O

Molecular Formula

C19H15N3OS

Molecular Weight

333.41

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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