AY 9944
Product Specifications
CAS Number
366-93-8
Target
Others
Related Pathways
Others
Purity
0.9965
Bioactivity
AY 9944 is a specific cholesterol biosynthesis inhibitor that targets the 7-dehydrocholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM) . At high doses, AY 9944 also inhibits sterol Δ7-Δ8 isomerase in cultured embryos, leading to the accumulation of cholest-8-en-3β-ol[1][2][3]. Additionally, AY 9944 causes hypocholesterolemia and accumulation of 7DHC.
Smiles
Cl.Cl.Clc1ccccc1CNC[C@H]1CC[C@H](CNCc2ccccc2Cl)CC1
Molecular Formula
C22H30Cl4N2
Molecular Weight
464.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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