ARCC-4

Product Specifications

CAS Number

1973403-00-7

Target

PROTACs|||Androgen Receptor

Related Pathways

Endocrinology/Hormones|||PROTAC

Bioactivity

ARCC-4 is an enzalutamide-based von Hippel-Lindau (VHL) -recruiting AR PROTAC and outperforms enzalutamide and it is a low-nanomolar androgen receptor (AR) degrader based on PROTAC, with a DC50 of 5 nM. ARCC-4 effectively degrades clinically relevant AR mutants associated with antiandrogen therapy[1].

Smiles

Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCCOc2ccc(cc2)-c2ccc(cc2)N2C(=S)N(C(=O)C2(C)C)c2ccc(C#N)c(c2)C(F)(F)F)C(C)(C)C)cc1

Molecular Formula

C53H56F3N7O7S2

Molecular Weight

1024.18

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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