Apratastat
Product Specifications
CAS Number
287405-51-0
Target
MMP, TNF
Related Pathways
Proteases/Proteasome, Apoptosis
Bioactivity
Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs) and it also can potently inhibit the release of TNF-α in vitro, ex vivo, and in vivo with IC50s of 144 ng/mL in vitro and 81.7 ng/mL ex vivo, respectively[1].
Smiles
CC1(C)SCCN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(OCC#CCO)cc1
Molecular Formula
C17H22N2O6S2
Molecular Weight
414.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6386180-01 0.1 mL
MUTYH (A/G-specific Adenine DNA Glycosylase, MutY Homolog, hMYH, MYH) (MaxLight 750)
Sign In for Pricing
View Details MBS6386180-02 5x 0.1 mL
MUTYH (A/G-specific Adenine DNA Glycosylase, MutY Homolog, hMYH, MYH) (MaxLight 750)
Sign In for Pricing
View Details 
