Apratastat
Product Specifications
CAS Number
287405-51-0
Target
MMP, TNF
Related Pathways
Proteases/Proteasome, Apoptosis
Bioactivity
Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs) and it also can potently inhibit the release of TNF-α in vitro, ex vivo, and in vivo with IC50s of 144 ng/mL in vitro and 81.7 ng/mL ex vivo, respectively[1].
Smiles
CC1(C)SCCN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(OCC#CCO)cc1
Molecular Formula
C17H22N2O6S2
Molecular Weight
414.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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