What is the catalog number for Alrizomadlin?

The catalog number for Alrizomadlin is T14303.

What sizes are available for Alrizomadlin?

Alrizomadlin is available in the following size(s): 1 mg, 5 mg, 1 mL - 10 mM (in DMSO), 10 mg, 25 mg, 50 mg, 100 mg.

How many pack sizes does Alrizomadlin come in?

Alrizomadlin is available in 7 different pack sizes.

Is Alrizomadlin in stock?

Alrizomadlin is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Alrizomadlin?

Alrizomadlin is manufactured by Molfinity.

What is the estimated delivery time for Alrizomadlin?

Estimated delivery time for Alrizomadlin is approximately 10 business day(s), depending on your location.

Alrizomadlin

Product Specifications

CAS Number

1818393-16-6

Target

MDM-2/p53, E1/E2/E3 Enzyme, Mdm2, Apoptosis

Related Pathways

Apoptosis, Ubiquitination

Purity

0.9947

Bioactivity

Alrizomadlin is an orally active MDM2 inhibitor. APG-115 shows significant dose-dependent inhibitory effects on TP53wt AML cell lines. The IC50 values are 26.8 nM for MOLM-13 cells and 165.9 nM for MV-4-11 cells. , OCI-AML-3 cells 315.6 nM. Alrizomadlin blocks the interaction of MDM2 and p53 and induces cell cycle arrest and apoptosis in a p53-dependent manner.