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Alrizomadlin

Product Specifications

CAS Number

1818393-16-6

Target

MDM-2/p53|||E1/E2/E3 Enzyme|||Mdm2|||Apoptosis

Related Pathways

Apoptosis|||Ubiquitination

Purity

0.9947

Bioactivity

Alrizomadlin is an orally active MDM2 inhibitor. APG-115 shows significant dose-dependent inhibitory effects on TP53wt AML cell lines. The IC50 values ??are 26.8 nM for MOLM-13 cells and 165.9 nM for MV-4-11 cells. , OCI-AML-3 cells 315.6 nM. Alrizomadlin blocks the interaction of MDM2 and p53 and induces cell cycle arrest and apoptosis in a p53-dependent manner.

Smiles

CCN1[C@H]([C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc3cc(Cl)ccc23)C11CCCCC1)C(=O)NC12CCC(CC1)(CC2)C(O)=O

Molecular Formula

C34H38Cl2FN3O4

Molecular Weight

642.59

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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