AMD 3465
Product Specifications
CAS Number
185991-24-6
Target
HIV Protease, CXCR
Related Pathways
Immunology/Inflammation, Proteases/Proteasome, Microbiology/Virology, GPCR/G Protein, Autophagy
Bioactivity
AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM) . However, it has no effect on CCR5-using (R5) viruses. AMD 3465 (GENZ-644494) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells.
Smiles
N=1C=CC=CC1CNCC2=CC=C(C=C2)CN3CCNCCCNCCNCCC3
Molecular Formula
C24H38N6
Molecular Weight
410.6
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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