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Alpelisib hydrochloride

Product Specifications

CAS Number

1584128-91-5

Target

PI3K

Related Pathways

PI3K/Akt/mTOR signaling

Purity

0.9764

Bioactivity

Alpelisib hydrochloride (BYL-719 hydrochloride) is a potent PI3Kα inhibitor (IC50 = 5 nM) with selectivity and oral bioavailability, exhibiting activity against PI3Kβ/γ/δ that is dozens of times weaker than against PI3Kα (IC50 = 250/290/1200 nM) . Alpelisib exhibits targeting activity against PIK3CA-mutated tumors and may be utilized in cancer research.

Smiles

CC1=C(C=2C=C(C(C(F)(F)F)(C)C)N=CC2)SC(NC(=O)N3[C@H](C(N)=O)CCC3)=N1.Cl

Molecular Formula

C19H23ClF3N5O2S

Molecular Weight

477.93

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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