Pelitrexol
Product Specifications
CAS Number
446022-33-9
Target
Antifolate, mTOR, DHFR
Related Pathways
Cell Cycle/Checkpoint, DNA Damage/DNA Repair, PI3K/Akt/mTOR signaling, Metabolism
Purity
0.9803
Bioactivity
Pelitrexol (AG2037) is a GARFT inhibitor, which can inhibit the activity of mTORC1, reduce intracellular guanine nucleotides and block the cell cycle in the s-phase, with antiproliferative activity, and can be used in non-small cell lung cancer.
Smiles
O=C1C2=C(NC[C@@H](CCC=3SC(C(N[C@@H](CCC(O)=O)C(O)=O)=O)=CC3C)C2)NC(N)=N1
Molecular Formula
C20H25N5O6S
Molecular Weight
463.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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