AGN-195183
Product Specifications
CAS Number
367273-07-2
Target
Autophagy|||Retinoid Receptor|||Others
Related Pathways
Autophagy|||Others|||Metabolism
Bioactivity
AGN 195183 is a potent and selective agonist of RAR? (Kd=3 nM) with improved binding selectivity relative to AGN 193836; no activity on RAR?/?. IC50 value: 3 nM (Kd) ; 200 nM (EC80, RAR Trans.) Target: RAR? agonist Compound 4 (AGN-195183) inhibited the growth of breast cancer cell lines, and was inactive in an in vivo model of topical irritation. Compound 4 (AGN 195183) is currently in Phase I/IIA clinical trials in cancer patients. Compound 4 and ATRA inhibit growth of the human breast cancer cell lines, T-47D and SK-BR-3, however it does not cause the topical irritation induced by the RARa-selective retinoid, Am-580.
Smiles
CC1(C)CCC(C)(C)c2c(Cl)c(O)c(cc12)C(=O)Nc1cc(F)c(C(O)=O)c(F)c1
Molecular Formula
C22H22ClF2NO4
Molecular Weight
437.86
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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