A-443654

Product Specifications

CAS Number

552325-16-3

Target

PKA, PKC, Src, Chk, VEGFR, Akt, FLT, Casein Kinase, ERK, MAPK, GSK-3, S6 Kinase, CDK

Related Pathways

Cell Cycle/Checkpoint, Stem Cells, MAPK, Cytoskeletal Signaling, PI3K/Akt/mTOR signaling, Angiogenesis, Chromatin/Epigenetic, Tyrosine Kinase/Adaptors, Metabolism

Purity

0.9951

Bioactivity

A-443654, a pan-Akt inhibitor, exhibits equal potency against Akt1, Akt2, and Akt3 within cells (Ki=160 pM) .

Smiles

C([C@@H](COC=1C=C(C=NC1)C=2C=C3C(=CC2)NN=C3C)N)C=4C=5C(NC4)=CC=CC5

Molecular Formula

C24H23N5O

Molecular Weight

397.47

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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