7α,25-Dihydroxycholesterol
Product Specifications
CAS Number
64907-22-8
Target
Endogenous Metabolite, EBI2/GPR183
Related Pathways
Metabolism, GPCR/G Protein
Bioactivity
7α,25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist, as well as an endogenous ligand, of the orphan GPCR receptor EBI2 (GPR183) . It serves as a chemokine directing the migration of B cells, T cells, and dendritic cells and exhibits high potency in activating EBI2 (EC50=140 pM; Kd=450 pM) [1][2].
Smiles
C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
Molecular Formula
C27H46O3
Molecular Weight
418.65
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Frequently Asked Questions
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