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1-Naphthohydroxamic acid

Product Specifications

CAS Number

6953-61-3

Target

HDAC

Related Pathways

DNA Damage/DNA Repair, Chromatin/Epigenetic

Purity

>99.99%

Bioactivity

1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM, demonstrating greater selectivity for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM) . It does not increase global histone H4 acetylation or reduce total intracellular HDAC activity but can induce tubulin acetylation[1][2].

Smiles

ONC(=O)c1cccc2ccccc12

Molecular Formula

C11H9NO2

Molecular Weight

187.19

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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