1-Naphthohydroxamic acid
Product Specifications
CAS Number
6953-61-3
Target
HDAC
Related Pathways
DNA Damage/DNA Repair|||Chromatin/Epigenetic
Purity
>99.99%
Bioactivity
1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 ?M, demonstrating greater selectivity for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 ?M) . It does not increase global histone H4 acetylation or reduce total intracellular HDAC activity but can induce tubulin acetylation[1][2].
Smiles
ONC(=O)c1cccc2ccccc12
Molecular Formula
C11H9NO2
Molecular Weight
187.19
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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