VHL Ligand 8
Product Specifications
CAS Number
2701565-76-4
Target
Others, Ligand for E3 Ligase
Related Pathways
PROTAC, Others
Bioactivity
VHL Ligand 8, a VHL ligand essential for synthesizing ARD-266, acts as a highly potent VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. It efficiently facilitates the degradation of AR protein in AR-positive prostate cancer cell lines LNCaP, VCaP, and 22Rv1, exhibiting DC50 values ranging from 0.2-1 nM [1].
Smiles
C([C@H](C(C)C)C=1ON=C(C)C1)(=O)N2[C@H](C(N[C@@H](CC(O)=O)C3=CC=CC=C3)=O)C[C@@H](O)C2
Molecular Formula
C23H29N3O6
Molecular Weight
443.49
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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