Sulfo-ara-F-NMN
Product Specifications
CAS Number
1374663-29-2
Target
Others, TLR
Related Pathways
Immunology/Inflammation, Others
Bioactivity
Sulfo-ara-F-NMN is an analogue of nicotinamide mononucleotide (NMN) with cellular permeability. Sulfo-ara-F-NMN was selective to activate SARM1 and inhibited CD38 with an IC50 of about 10 μM. Activation by Sulfo-ara-F-NMN to Z-48 or NMN, which has a higher cyclase activity, causes conformational changes in SARM1, resulting in cADPR production, NAD depletion, and non-apoptotic cell death.
Smiles
F[C@@H]1[C@@H](O[C@H](COP(=O)([O-])S)[C@H]1O)[N+]=2C=C(C(N)=O)C=CC2
Molecular Formula
C11H14FN2O6PS
Molecular Weight
352.28
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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