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L-2-Hydroxyglutaric acid

Product Specifications

CAS Number

13095-48-2

Target

Histone Demethylase|||Endogenous Metabolite|||Mitochondrial Metabolism

Related Pathways

Metabolism|||Chromatin/Epigenetic

Bioactivity

L-2-Hydroxyglutaric acid (L-2-HG) is a compartmentalized metabolite and a substrate for L-2-hydroxyglutarate dehydrogenase (L2HGDH) . It inhibits histone demethylases and increases the expression of ATF4 and its target genes by activating the mTOR pathway. L-2-Hydroxyglutaric acid mediates the mTOR-ATF4 signaling pathway and can be used in biosensor research.

Smiles

[C@H](CCC(O)=O)(C(O)=O)O

Molecular Formula

C5H8O5

Molecular Weight

148.11

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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