L-2-Hydroxyglutaric acid
Product Specifications
CAS Number
13095-48-2
Target
Histone Demethylase, Endogenous Metabolite, Mitochondrial Metabolism
Related Pathways
Metabolism, Chromatin/Epigenetic
Bioactivity
L-2-Hydroxyglutaric acid (L-2-HG) is a compartmentalized metabolite and a substrate for L-2-hydroxyglutarate dehydrogenase (L2HGDH) . It inhibits histone demethylases and increases the expression of ATF4 and its target genes by activating the mTOR pathway. L-2-Hydroxyglutaric acid mediates the mTOR-ATF4 signaling pathway and can be used in biosensor research.
Smiles
[C@H](CCC(O)=O)(C(O)=O)O
Molecular Formula
C5H8O5
Molecular Weight
148.11
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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