JH-XI-10-02
Product Specifications
CAS Number
2209085-22-1
Target
EGFR, PROTACs, CDK
Related Pathways
PROTAC, Tyrosine Kinase/Adaptors, Angiogenesis, JAK/STAT signaling, Cell Cycle/Checkpoint
Bioactivity
JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19. JH-XI-10-02 is a potent and selective degrader of CDK8, with an IC50 of 159 nM, based on PROTAC.
Smiles
[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC[C@@]4([H])C[C@H](CC[C@]4(C)[C@@]3([H])CC[C@]12C)N(C)C(=O)CCOCCOCCOCCOCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12)c1ccc2ccncc2c1
Molecular Formula
C53H69N5O9
Molecular Weight
920.161
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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