ILS-920
Product Specifications
CAS Number
892494-07-4
Target
Others, Calcium Channel, FKBP
Related Pathways
Membrane transporter/Ion channel, Others, Immunology/Inflammation, Metabolism, Apoptosis, Autophagy
Bioactivity
ILS-920 is a Rapamycin analog characterized by diminished immunosuppressive effects but remarkable neuroprotective properties. It exhibits selective binding affinity towards the immunophilin FKBP52 as well as the β1-subunit of L-type voltage-gated calcium channels (VGCC) . ILS-920 displays a notable 200-fold preference for FKBP52 over FKBP12.
Smiles
C[C@@H]1[C@]2(N(O[C@](CC2)(/C=C(\C)/[C@@H](OC)C[C@]3(O[C@@](O)(C(=O)C(=O)N4[C@](C(=O)O[C@]([C@@H](C[C@H]5C[C@@H](OC)[C@H](O)CC5)C)(CC(=O)[C@H](C)/C=C(\C)/[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C1)[H])(CCCC4)[H])[C@H](C)CC3)[H])[H])C6=CC=CC=C6)[H]
Molecular Formula
C57H86N2O14
Molecular Weight
1023.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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