Homocarbonyltopsentin

Product Specifications

CAS Number

172286-77-0

Target

Others|||DNA/RNA Synthesis

Related Pathways

Others|||DNA Damage/DNA Repair|||Cell Cycle/Checkpoint

Bioactivity

Homocarbonyltopsentin is a small-molecule TSL2-binding compound, binds to pentaloop conformations of TSL2 and promotes a shift to triloop conformations that display enhanced SMN2 exon 7 (E7) splicing (EC50: 16 ?M) .

Smiles

Oc1ccc2c(c[nH]c2c1)C(=O)c1ncc([nH]1)C(=O)c1c[nH]c2ccccc12

Molecular Formula

C21H14N4O3

Molecular Weight

370.36

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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