(S, R, S) -AHPC-Me dihydrochloride
Product Specifications
Target
Ligand for E3 Ligase, Others
Related Pathways
Others, PROTAC
Bioactivity
(S, R, S) -AHPC-Me dihydrochloride, also known as VHL ligand 2 dihydrochloride, is a chemical compound used in the synthesis of ARV-771. ARV-771 is a BET PROTAC degrader that relies on von Hippel-Landau (VHL) E3 ligase and exhibits potent degradation of BET proteins in castration-resistant prostate cancer (CRPC) cells, with a DC50 of less than 1 nM. This compound acts as the VHL ligand, specifically the (S, R, S) -AHPC-based VHL ligand, facilitating the recruitment of von Hippel-Lindau (VHL) protein.
Smiles
N[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O.Cl.Cl
Molecular Formula
C23H34Cl2N4O3S
Molecular Weight
517.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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