ARI-1
ARI-1 is a receptor tyrosine kinase-like orphan receptor 1 (ROR1) inhibitor. ARI-1 blocks the PI3K/AKT/mTOR signaling pathway in a ROR1-dependent manner. ARI-1 upregulates cleaved-PARP and p-P38. ARI-1 induces Apoptosis. ARI-1 has anticancer activity against non-small cell lung cancer[1].
Product Specifications
UNSPSC
12352005
Target
Akt; Apoptosis; mTOR; PARP; ROR
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ari-1.html
Purity
99.16
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C[C@H](C2=CC=C(OC)C=C2)OC3=C1C(OCOC)=CC(OCOC)=C3
Molecular Formula
C20H22O7
Molecular Weight
374.38
References & Citations
[1]Liu X, et al. Novel ROR1 inhibitor ARI-1 suppresses the development of non-small cell lung cancer. Cancer Lett. 2019 Aug 28,458:76-85.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Lentiviral mouse Ptger1 shRNA (UAS) - Lentiviral mousePtger1 shRNA (UAS, GFP) (25)
![Rabbit Polyclonal PNPT1 Antibody [Alexa Fluor 647]](https://cdn.genprice.uk/genprice/uk/genprice2.webp)
Rabbit Polyclonal PNPT1 Antibody [Alexa Fluor 647]
Lentiviral mouse Vpreb3 shRNA (UAS) - Lentiviral mouse Vpreb3 shRNA (UAS, GFP) plasmid
