VA012
VA012 (compound 11) is a positive allosteric modulator (PAM) of the serotonin 5-HT2C receptor. VA012 reduces food intake and body weight gain without causing CNS-related malaise during subchronic administration. VA012 can be utilized in obesity research[1].
Product Specifications
CAS Number
885898-58-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/va012.html
Purity
99.34
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N1(CC2=CC=CC=C2)C=C(CNC3=CC=CN=C3)C4=C1C=CC=C4
Molecular Formula
C21H19N3
Molecular Weight
313.40
Precautions
H302, H315, H319, H335
References & Citations
[1]García-Cárceles J, et al. A Positive Allosteric Modulator of the Serotonin 5-HT2C Receptor for Obesity. J Med Chem. 2017 Dec 14;60 (23) :9575-9584.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor
Available Sizes
Frequently Asked Questions
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