VA012

VA012 (compound 11) is a positive allosteric modulator (PAM) of the serotonin 5-HT2C receptor. VA012 reduces food intake and body weight gain without causing CNS-related malaise during subchronic administration. VA012 can be utilized in obesity research[1].

Product Specifications

CAS Number

[885898-58-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/va012.html

Purity

99.34

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

N1(CC2=CC=CC=C2)C=C(CNC3=CC=CN=C3)C4=C1C=CC=C4

Molecular Formula

C21H19N3

Molecular Weight

313.40

Precautions

H302, H315, H319, H335

References & Citations

[1]García-Cárceles J, et al. A Positive Allosteric Modulator of the Serotonin 5-HT2C Receptor for Obesity. J Med Chem. 2017 Dec 14;60 (23) :9575-9584.