CDDO-dhTFEA
Product Specifications
CAS Number
1191265-33-4
Target
Apoptosis, NF-κB, Nrf2
Related Pathways
Apoptosis, NF-κB, Immunology/Inflammation
Purity
0.9959
Bioactivity
CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor. It restores mean arterial pressure (MAP), elevates Nrf2 levels and the expression of related genes, attenuates NF-κB and transforming growth factor-β pathway activation, and mitigates glomerulosclerosis, interstitial fibrosis, and inflammation in rats with chronic kidney disease (CKD) .
Smiles
[H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)[C@]2([H])C(=O)C[C@@]2([H])[C@@]1(C)CC[C@@]1([H])C(C)(C)C(=O)C(=C[C@]21C)C#N)C(=O)NCC(F)(F)F
Molecular Formula
C33H45F3N2O3
Molecular Weight
574.72
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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