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β-Amanitin

Product Specifications

CAS Number

21150-22-1

Target

DNA/RNA Synthesis, ADC Cytotoxin

Related Pathways

DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Antibody-drug Conjugate/ADC Related

Bioactivity

β-Amanitin, a cyclic peptide toxin found in the poisonous Amanita phalloides mushroom, inhibits eukaryotic RNA polymerase II and III, thereby disrupting protein synthesis.

Smiles

[H][C@@]12C[C@@H](O)CN1C(=O)[C@]([H])(CC(O)=O)NC(=O)[C@]1([H])C[S@](=O)c3[nH]c4cc(O)ccc4c3C[C@]([H])(NC(=O)[C@@]([H])(NC2=O)[C@@H](C)[C@@H](O)CO)C(=O)NCC(=O)N[C@@]([H])([C@@H](C)CC)C(=O)NCC(=O)N1

Molecular Formula

C39H53N9O15S

Molecular Weight

919.96

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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