β-Amanitin
Product Specifications
CAS Number
21150-22-1
Target
DNA/RNA Synthesis, ADC Cytotoxin
Related Pathways
DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Antibody-drug Conjugate/ADC Related
Bioactivity
β-Amanitin, a cyclic peptide toxin found in the poisonous Amanita phalloides mushroom, inhibits eukaryotic RNA polymerase II and III, thereby disrupting protein synthesis.
Smiles
[H][C@@]12C[C@@H](O)CN1C(=O)[C@]([H])(CC(O)=O)NC(=O)[C@]1([H])C[S@](=O)c3[nH]c4cc(O)ccc4c3C[C@]([H])(NC(=O)[C@@]([H])(NC2=O)[C@@H](C)[C@@H](O)CO)C(=O)NCC(=O)N[C@@]([H])([C@@H](C)CC)C(=O)NCC(=O)N1
Molecular Formula
C39H53N9O15S
Molecular Weight
919.96
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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