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VU591 hydrochloride

Product Specifications

CAS Number

1315380-70-1

Target

Potassium Channel

Related Pathways

Membrane transporter/Ion channel

Purity

0.9995

Bioactivity

VU591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50:0.24 ?M) . Thought to block the intracellular pore of the Kir1.1 channel. Exhibits no effect on Kir7.1 at concentrations up to 10 ?M; does not inhibit Kir2.1, Kir2.3 or Kir4.1. Displays similar potency to VU 590

Smiles

Cl.[O-][N+](=O)c1ccc2nc(COCc3nc4ccc(cc4[nH]3)[N+]([O-])=O)[nH]c2c1

Molecular Formula

C16H13ClN6O5

Molecular Weight

404.76

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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