VU591 hydrochloride
Product Specifications
CAS Number
1315380-70-1
Target
Potassium Channel
Related Pathways
Membrane transporter/Ion channel
Purity
0.9995
Bioactivity
VU591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50:0.24 ?M) . Thought to block the intracellular pore of the Kir1.1 channel. Exhibits no effect on Kir7.1 at concentrations up to 10 ?M; does not inhibit Kir2.1, Kir2.3 or Kir4.1. Displays similar potency to VU 590
Smiles
Cl.[O-][N+](=O)c1ccc2nc(COCc3nc4ccc(cc4[nH]3)[N+]([O-])=O)[nH]c2c1
Molecular Formula
C16H13ClN6O5
Molecular Weight
404.76
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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