UK-101
Product Specifications
CAS Number
1000313-40-5
Target
Apoptosis|||Proteasome
Related Pathways
Apoptosis|||Proteases/Proteasome|||Ubiquitination
Purity
>99.99%
Bioactivity
UK-101 is a potent and selective inhibitor of the immunoproteasome LMP2, inhibiting ?1i (LMP2), ?1c (LMP2), and ?5 (LMP2), with IC50s of 104 nM, 15 ?M, and 1 ?M, respectively. UK-101 exhibits a 144-fold and 10-fold higher affinity for ?1i than for the distribution of ?1c and ?5 subunits. UK-101 induces apoptosis and can be used to study prostate cancer-related diseases.
Smiles
C([C@@H](NC([C@@H](NC(CCCCCC)=O)C)=O)CC(C)C)(=O)[C@@]1(CO[Si](C(C)(C)C)(C)C)CO1
Molecular Formula
C25H48N2O5Si
Molecular Weight
484.74
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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