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PKM2-IN-1

PKM2-IN-1 (compound 3k) is a pyruvate kinase M2 (PKM2) inhibitor with an IC50 of 2.95 μM[1].

Product Specifications

CAS Number

94164-88-2

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Pyruvate Kinase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PKM2-IN-1.html

Concentration

10mM

Purity

99.79

Solubility

DMSO : 4 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

S=C(N1CCCCC1)SCC(C2=O)=C(C)C(C3=C2C=CC=C3)=O

Molecular Formula

C18H19NO2S2

Molecular Weight

345.48

Precautions

H302, H315, H319, H335

References & Citations

[1]Ning X, et al. Discovery of novel naphthoquinone derivatives as inhibitors of the tumor cell specific M2 isoform of pyruvate kinase. Eur J Med Chem. 2017 Sep 29;138:343-352.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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