PKM2-IN-1
PKM2-IN-1 (compound 3k) is a pyruvate kinase M2 (PKM2) inhibitor with an IC50 of 2.95 μM[1].
Product Specifications
CAS Number
[94164-88-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Pyruvate Kinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PKM2-IN-1.html
Concentration
10mM
Purity
99.79
Solubility
DMSO : 4 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
S=C(N1CCCCC1)SCC(C2=O)=C(C)C(C3=C2C=CC=C3)=O
Molecular Formula
C18H19NO2S2
Molecular Weight
345.48
Precautions
H302, H315, H319, H335
References & Citations
[1]Ning X, et al. Discovery of novel naphthoquinone derivatives as inhibitors of the tumor cell specific M2 isoform of pyruvate kinase. Eur J Med Chem. 2017 Sep 29;138:343-352.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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