Thalidomide-O-amido-C4-N3

Thalidomide-O-amido-C4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-amido-C4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[2098488-36-7]

Product Name Alternative

Cereblon Ligand-Linker Conjugates 4; E3 ligase Ligand-Linker Conjugates 18

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; PROTAC

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/E3_ligase_Ligand-Linker_Conjugates_18.html

Purity

98.36

Solubility

DMSO : ≥ 41 mg/mL

Smiles

O=C(N(C(CCC1=O)C(N1)=O)C2=O)C(C2=CC=C3)=C3OCC(NCCCCN=[N+]=[N-])=O

Molecular Formula

C19H20N6O6

Molecular Weight

428.40

Precautions

H302, H315, H319, H335

References & Citations

[1]Schiedel M, et al. Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals) . J Med Chem. 2018 Jan 25;61 (2) :482-491.