T6167923
Product Specifications
CAS Number
2437475-16-4
Target
MyD88
Related Pathways
Immunology/Inflammation
Purity
0.9928
Bioactivity
T6167923 is a potent, selective inhibitor of MyD88-dependent signaling pathways. It achieves this by directly binding to the Toll/IL1 receptor (TIR) domain of MyD88, preventing MyD88 homodimer formation. Subsequently, T6167923 impedes NF-κB driven Staphylococcus enterotoxin AP (SEAP) activity and boasts improved anti-inflammatory effects, with IC50s values of 2.7 μM for IFN-γ, 2.9 μM for IL-1β, and 2.66 μM each for IL-6 and TNF-α, demonstrating its efficacy across multiple inflammatory mediators [1].
Smiles
C[C@H](NC(=O)N1CCN(CC1)S(=O)(=O)c1cccc(Br)c1)c1cccs1
Molecular Formula
C17H20BrN3O3S2
Molecular Weight
458.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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