TCO-PEG-TCO (MW 5000)

TCO-PEG-TCO (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. TCO-PEG-TCO (MW 5000) is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

Product Specifications

UNSPSC

12352211

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tco-peg-tco-mw-5000.html

Purity

97.12

Solubility

10 mM in DMSO

Smiles

O=C(NCCOCCNC(OC1CC/C=C\CCC1)=O)OC2CC/C=C\CCC2.[MW5000].[n]

Molecular Weight

5000 (Average)

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562